Cell: Cardiogenic miRNA that regulates energy balance
Researchers from the University of Texas Southwestern Medical Center have demonstrated for the first time in a new study that manipulating small molecules in the heart can regulate the energy balance of the entire body. This research may indicate more for diseases such as obesity, diabetes and heart disease. Effective treatment strategy. The results of the study were published online in the journal Cell on April 27.
According to statistics from the Centers for Disease Control and Prevention, tens of millions of people in the United States are affected by obesity, cardiovascular disease, and diabetes.
Using high-fat diets to feed mice, the researchers found that manipulating a heart-specific genetic signaling pathway can prevent obesity and protect against type 2 diabetes associated with harmful blood sugar changes.
After genetic manipulation or drug treatment, mice with increased MED13 levels showed weight loss and showed increased energy expenditure. In contrast, genetically engineered mice with missing MED13 in their hearts have increased susceptibility to diet-induced obesity. These mice also showed abnormal blood glucose metabolism and changes similar to the symptoms of a group of diseases called metabolic syndrome, which are related to the occurrence of coronary artery disease, stroke and type 2 diabetes and other diseases.
The current study is based on the original findings and determined the role of miR-208a and its target protein MED13 in regulating systemic metabolism. The lead author and postdoctoral researcher Chad Grueter said that this microRNA communication between cells throughout the body will become an important topic for their future research.
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