Researchers in Canada and the United States have found a new way to treat AIDS. The new method combines targeted chemotherapy with the more commonly used highly effective antiretroviral therapy, which provides a new possibility for the treatment of AIDS.
According to the scientists involved in the research work, this new treatment can not only kill viruses wandering around the human body, but also kill viruses hidden in immune cells. The value of this research achievement is that it has pointed the way forward for scientists studying AIDS treatment worldwide, and laid the foundation for finding a new and innovative AIDS treatment method. Related articles were published online in "Nature-Medicine" on June 21.
So far, the efficacy of anti-AIDS treatment has not been satisfactory because the virus is hidden in the cells of the immune system, and the currently used high-efficiency antiretroviral therapy has no way to deal with the virus hidden in the immune cells. Researchers in Canada and the United States have succeeded in identifying cells that harbored the virus and found a "stealth" mechanism by which the virus can escape existing treatments.
Professor Keene Roddy, a hematologist at McGill University who participated in the research, believes that the results of this research prove for the first time that the so-called HIV latent pool phenomenon is not due to the lack of effectiveness of antireversal drugs, but because the virus is hidden in two different types The long-lived CD4 memory is inside immune cells. There are several types of HIV latent pools, and each type of latent pool requires different treatments to eliminate them. Once the virus is hidden in these latent pool cells, they will become dependent on it. If the cell survives, the virus can survive, but if the cell dies, the virus cannot survive. Therefore, destroying these immune cells can kill these hidden viruses. Existing highly effective antiretroviral therapy can kill viruses circulating in the body, but it cannot deal with viruses hidden in cells of the immune system.
Professor Secary of the University of Montreal, who is in charge of the research, said that the results of this study are similar to the strategy used to treat leukemia, that is, the same is targeted chemotherapy, which is also combined with targeted immunotherapy. This method not only kills viruses in the cells, but also allows time for the immune system to regenerate healthy cells.
The researchers believe that the results obtained so far provide an important option for the development of new anti-HIV treatment methods, but it will take several years of further research work to enter the practical application.
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